Better Elasticity, More Firmness: Discover OS-01 EYE’s Clinical Results
6 min read
July 20, 2023
July 20,2023
ONESKIN PRODUCTS
Better Elasticity, More Firmness: Discover OS-01 EYE’s Clinical Results
6 min read
July 20, 2023
July 20,2023
ONESKIN PRODUCTS
We’re excited to share another piece of evidence in support of OS-01 EYE, our specialized treatment to target and reduce signs of aging and functional decline in the delicate skin around the eyes. Backed by extensive lab and beta testing before launch, OS-01 EYE is also clinically validated to increase elasticity, firmness, and hydration around the eyes. Join us as we share the methods behind the clinical study–and how these results confirm the extensive evidence gathered in the OneSkin lab.
We’re excited to share another piece of evidence in support of OS-01 EYE, our specialized treatment to target and reduce signs of aging and functional decline in the delicate skin around the eyes. Backed by extensive lab and beta testing before launch, OS-01 EYE is also clinically validated to increase elasticity, firmness, and hydration around the eyes. Join us as we share the methods behind the clinical study–and how these results confirm the extensive evidence gathered in the OneSkin lab.
01
What’s the difference between lab data & clinical data?
Before we dive into the results of our clinical study, here’s a quick refresher on the different kinds of studies we conduct on our products here at OneSkin.
- Lab Data: Conducted by our in-house team of scientists on skin cells and skin samples, our lab research reveals the effects of our products on tissue health, genetic expression, and other cellular processes. This testing ensures that our products target skin health and longevity on the cellular level – increasing our confidence that our products will deliver meaningful, long-lasting results.
- Clinical Data: It’s only once we fully understand the cellular impacts of our products that we test them in clinical studies to observe their effects on real people. In partnership with a third-party research organization, we test our finished products on volunteers for a period of at least 12 weeks, then measure their impacts on factors like hydration, firmness, and more.
01
What’s the difference between lab data & clinical data?
Before we dive into the results of our clinical study, here’s a quick refresher on the different kinds of studies we conduct on our products here at OneSkin.
- Lab Data: Conducted by our in-house team of scientists on skin cells and skin samples, our lab research reveals the effects of our products on tissue health, genetic expression, and other cellular processes. This testing ensures that our products target skin health and longevity on the cellular level – increasing our confidence that our products will deliver meaningful, long-lasting results.
- Clinical Data: It’s only once we fully understand the cellular impacts of our products that we test them in clinical studies to observe their effects on real people. In partnership with a third-party research organization, we test our finished products on volunteers for a period of at least 12 weeks, then measure their impacts on factors like hydration, firmness, and more.
02
What makes OS-01 EYE special?
The skin around your eyes has been shown to age faster than the rest of the skin with higher levels of senescent cells. (1) The secretion of inflammatory signals by senescent cells is known to contribute to the degradation of collagen, resulting in a loss of skin firmness and resilience, which manifests as wrinkling and sagging. (2, 3) That's why the OS-01 peptide, which blocks inflammatory signals by senescent cells, is the perfect ingredient to tackle advanced senescence around the eyes. (4) Combined with actives known to boost collagen production and increase moisturization, such as acetyl hexapeptide-8, Fucus vesiculosus extract, Moringa oleifera seed extract, and hyaluronic acid, OS-01 EYE delivers a synergistic formula strategically designed to mitigate the exacerbated effects of aging in the delicate eye area skin.
02
What makes OS-01 EYE special?
The skin around your eyes has been shown to age faster than the rest of the skin with higher levels of senescent cells. (1) The secretion of inflammatory signals by senescent cells is known to contribute to the degradation of collagen, resulting in a loss of skin firmness and resilience, which manifests as wrinkling and sagging. (2, 3) That's why the OS-01 peptide, which blocks inflammatory signals by senescent cells, is the perfect ingredient to tackle advanced senescence around the eyes. (4) Combined with actives known to boost collagen production and increase moisturization, such as acetyl hexapeptide-8, Fucus vesiculosus extract, Moringa oleifera seed extract, and hyaluronic acid, OS-01 EYE delivers a synergistic formula strategically designed to mitigate the exacerbated effects of aging in the delicate eye area skin.
03
What were the results of OS-01 EYE’s clinical study?
After putting our eye treatment to the test for 12 weeks, our third-party research partners observed the following noticeable improvements in skin health.
- Better elasticity: 86% of users showed a marked improvement in under-eye skin elasticity with an average improvement of +23.58%*
- Firmer skin: 73% of users showed a significant improvement in skin firmness with an average improvement of +10.19%.*
- Improved skin appearance: After just 4 weeks, 96% of users reported that the overall appearance of their under-eye skin improved with the daily use of OS-01 EYE.**
03
What were the results of OS-01 EYE’s clinical study?
After putting our eye treatment to the test for 12 weeks, our third-party research partners observed the following noticeable improvements in skin health.
- Better elasticity: 86% of users showed a marked improvement in under-eye skin elasticity with an average improvement of +23.58%*
- Firmer skin: 73% of users showed a significant improvement in skin firmness with an average improvement of +10.19%.*
- Improved skin appearance: After just 4 weeks, 96% of users reported that the overall appearance of their under-eye skin improved with the daily use of OS-01 EYE.**
04
How do these results confirm lab findings?
While we were thrilled to learn that OS-01 EYE showed such a meaningful impact in clinical studies, we weren’t exactly surprised. That’s because we had already proven that OS-01 EYE promotes healthy collagen levels in our lab research. Because collagen is the main structural protein that supports both skin elasticity and firmness, our lab data predicted that OS-01 EYE would show these changes even before our clinical tests were performed.In lab studies observing the expression of key biomarkers associated with collagen production (COL1A1) and degradation (MMP1) on human eyelid skin samples, OS-01 EYE was shown to improve collagen biosynthesis and retention at the cellular level. (5)
04
How do these results confirm lab findings?
While we were thrilled to learn that OS-01 EYE showed such a meaningful impact in clinical studies, we weren’t exactly surprised. That’s because we had already proven that OS-01 EYE promotes healthy collagen levels in our lab research. Because collagen is the main structural protein that supports both skin elasticity and firmness, our lab data predicted that OS-01 EYE would show these changes even before our clinical tests were performed.In lab studies observing the expression of key biomarkers associated with collagen production (COL1A1) and degradation (MMP1) on human eyelid skin samples, OS-01 EYE was shown to improve collagen biosynthesis and retention at the cellular level. (5)
The results are the average of testing in 3 different ex vivo eyelid skin samples grown from 42y, 59y, and 84y donors.
To further confirm that these biomarker results actually reflected increased collagen protein levels in the skin, we conducted another study on ex vivo human eyelid samples from a 70-year-old donor. We found that OS-01 EYE increased collagen protein levels by up to 2.3x. (5)
The results are the average of testing in 3 different ex vivo eyelid skin samples grown from 42y, 59y, and 84y donors.
To further confirm that these biomarker results actually reflected increased collagen protein levels in the skin, we conducted another study on ex vivo human eyelid samples from a 70-year-old donor. We found that OS-01 EYE increased collagen protein levels by up to 2.3x. (5)
Shown in lab studies on ex vivo human eyelid skin samples (70 yr) by analyzing levels of collagen in skin treated with OS-01 EYE compared to no treatment. Skin treated with OS-01 EYE displayed a significant increase compared to skin with no treatment. Data was measured in triplicate.
This functional increase in collagen levels is likely why OS-01 EYE shows such a significant impact on firmness, elasticity, and overall skin appearance after just a few months of use.
Shown in lab studies on ex vivo human eyelid skin samples (70 yr) by analyzing levels of collagen in skin treated with OS-01 EYE compared to no treatment. Skin treated with OS-01 EYE displayed a significant increase compared to skin with no treatment. Data was measured in triplicate.
This functional increase in collagen levels is likely why OS-01 EYE shows such a significant impact on firmness, elasticity, and overall skin appearance after just a few months of use.
05
What long-term impacts can we expect from OS-01 EYE?
Our products work at the cellular level, so they don’t promise instant results, but rather a gradual and lasting improvement in skin. Even so, twelve weeks is a relatively rapid timeline to observe the visible effects of cellular improvements in the skin, which is why we’re all the more excited about our clinical results. Powered by the highest concentration of our OS-01 peptide, OS-01 EYE was formulated to reduce accelerated skin aging that’s especially pronounced in delicate under-eye skin. Because the OS-01 peptide has been scientifically proven to reverse biological aging by targeting a root cause of skin aging, cellular senescence (4), we believe that OS-01 EYE will continue working to slow and prevent signs of aging like wrinkles, under-eye bags and more when used consistently. Anecdotally, our user reviews already reflect this reality, with reports of diminished fine lines, smoother texture, noticeable firmness and more. You can read what people have to say here.
05
What long-term impacts can we expect from OS-01 EYE?
Our products work at the cellular level, so they don’t promise instant results, but rather a gradual and lasting improvement in skin. Even so, twelve weeks is a relatively rapid timeline to observe the visible effects of cellular improvements in the skin, which is why we’re all the more excited about our clinical results. Powered by the highest concentration of our OS-01 peptide, OS-01 EYE was formulated to reduce accelerated skin aging that’s especially pronounced in delicate under-eye skin. Because the OS-01 peptide has been scientifically proven to reverse biological aging by targeting a root cause of skin aging, cellular senescence (4), we believe that OS-01 EYE will continue working to slow and prevent signs of aging like wrinkles, under-eye bags and more when used consistently. Anecdotally, our user reviews already reflect this reality, with reports of diminished fine lines, smoother texture, noticeable firmness and more. You can read what people have to say here.
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Key Takeaways:
- Eye area skin shows higher levels of senescent cells and advanced aging, requiring a specialized formula that will target the root cause of skin aging, like the OS-01 peptide.
- Before launching OS-01 EYE, we conducted extensive lab testing to validate its impacts on the cellular level.
- These tests showed that OS-01 EYE increased collagen levels in ex vivo human skin samples by 2.3x, giving us the confidence that our treatment functionally improves under-eye aging.
- Now, we’re happy to report that OS-01 EYE has been proven in clinical studies on human participants to improve firmness, elasticity and the overall appearance of skin.
- This data confirms what we already suspected: by blocking inflammatory signals from senescent cells and increasing collagen levels in the skin, OS-01 EYE can help the skin resist signs of aging including skin sagging & laxity.
Key Takeaways:
- Eye area skin shows higher levels of senescent cells and advanced aging, requiring a specialized formula that will target the root cause of skin aging, like the OS-01 peptide.
- Before launching OS-01 EYE, we conducted extensive lab testing to validate its impacts on the cellular level.
- These tests showed that OS-01 EYE increased collagen levels in ex vivo human skin samples by 2.3x, giving us the confidence that our treatment functionally improves under-eye aging.
- Now, we’re happy to report that OS-01 EYE has been proven in clinical studies on human participants to improve firmness, elasticity and the overall appearance of skin.
- This data confirms what we already suspected: by blocking inflammatory signals from senescent cells and increasing collagen levels in the skin, OS-01 EYE can help the skin resist signs of aging including skin sagging & laxity.
References
- New biological insights into skin aging around the eye. J. Am. Acad. Dermatol. 74, AB28 (2016).
- Wang, A. S. & Dreesen, O. Biomarkers of Cellular Senescence and Skin Aging. Front. Genet. 9, 247 (2018).
- Varani, J. et al. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am. J. Pathol. 168, 1861–1868 (2006).
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15 (2023).
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
References
- New biological insights into skin aging around the eye. J. Am. Acad. Dermatol. 74, AB28 (2016).
- Wang, A. S. & Dreesen, O. Biomarkers of Cellular Senescence and Skin Aging. Front. Genet. 9, 247 (2018).
- Varani, J. et al. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am. J. Pathol. 168, 1861–1868 (2006).
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15 (2023).
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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